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Docetaxel should not be used in patients hypersensitive to polysorbate 80, which is contained in the formulation. Patients with hepatic impairment show increased sensitivity to toxic effects of docetaxel, and should be given the drug with great care and in reduced doses, if at all.
Hypersensitivity: However, hypersensitivity reactions have also occurred with docetaxel and taxane cross-reactivity has been reported.
Tumour lysis syndrome: Fatal cases of tumour lysis syndrome have been reported after the second-line use of docetaxel.
